Renal Failure
What causes Renal (Kidney) Failure in dogs?
Renal failure (also known as kidney failure) is the end result of any one of a large number of diseases that can affect the kidneys and related organs. Technically, it occurs when the kidneys can no longer efficiently perform their function, which is to filter out toxins, maintain a normal electrolyte balance, regulate hydration, and secrete hormones needed for the production of red blood cells.
There are two broad types of kidney failure in dogs:
Acute renal failure: When kidney function suddenly declines (in hours or days), the process is referred to as acute. Acute renal failure in dogs is most commonly associated with infections and toxins.
Chronic renal failure: When the loss of function is more gradual (over weeks, months or years), it's called chronic renal failure. The most common cause of chronic renal failure in dogs is degeneration associated with geriatric decline. All kidneys have their own natural lifespan, but some dogs' kidneys deteriorate more quickly than others.
One of the most notable differences between acute and chronic kidney failure is that acute kidney failure is reversible if treated early and aggressively, whereas chronic kidney failure can only be managed.
The Causes of Kidney Failure
Kidney failure is ultimately caused by any disease affecting the kidneys. These include:
Bacterial infections - like leptospirosis, which the Centers for Disease Control and Prevention reports can be transmitted by drinking or swimming in contaminated water. This infection can lead to inflammation of the kidneys and consequent destruction of renal cells.
Toxicosis - or kidney poisoning - leads to damage of the kidneys' cells. It occurs when your dog ingests drugs (like ibuprofen) or poisons (like antifreeze or grapes). The ASPCA's Animal Poison Control Center lists these and other common household items that should be kept out of your dog's reach.
Congenital disease: Inherited conditions can lead to abnormal kidney function. The Merck Veterinary Manual includes a list of these congenital diseases, from cysts to agenesis (being born without one or both kidneys).
Geriatric degeneration: When kidneys get old, their cells can decline and die. This is, by far, the most common cause of kidney disease in dogs.
Symptoms of Kidney Failure
The most common signs of kidney failure in dogs include:
Vomiting
Increased drinking and urination
Lethargy
Weight loss
Pale mucous membranes in the mouth and elsewhere
The severity of clinical signs associated with kidney disease can vary depending on the presentation (acute or chronic), the extent to which the loss of kidney function has progressed and the underlying cause. Your vet can determine whether these signs point to a kidney problem or another issue, like diabetes mellitus.
Treating Kidney Failure in Dogs
The treatment of kidney failure varies depending on the underlying cause and the canine patient's overall condition. Dogs that are severely ill from acute kidney failure may need hospitalization and intensive care to recover. For milder cases, antibiotics, fluids, and other medications given on an outpatient basis can prove effective. Dialysis is even a possibility for a lucky few whose pet parents can afford the high cost of treatment.
In the case of chronic renal failure in dogs, treatment generally focuses on slowing the progression of disease and improving quality of life for the patient. Treatment of anemia, blood pressure alterations, electrolyte disturbances, fluid imbalances, nausea, and appetite changes is typically necessary. Most of these signs are managed through diet changes and medication. Pets can sometimes experience a good quality of life for years after a kidney failure diagnosis.
Preventing Renal Failure
Given that chronic renal failure in dogs is most commonly the result of genetically predetermined, age-related degeneration, it's not considered preventable. Nonetheless, regular physical examinations and wellness screenings can increase your dog's chances of early diagnosis and treatment.
Acute renal failure, however, is considered preventable in many instances. Vaccination against infectious diseases, like leptospirosis, for example, can prove highly effective. Clearing households of toxins, like antifreeze; being careful with grapes and raisins; and keeping all human medications out of the reach of dogs is also important.
The Role of Nutrition
Nutrition has long been a mainstay in the management of renal failure in dogs. Since maintaining electrolyte balance and managing blood proteins are a crucial part of the kidneys' role, altering the nutrients in a dog's diet can make kidney function easier. All dog parents whose pets suffer from kidney disease should talk to their veterinarian about the ideal therapeutic diet and any additional nutritional supplements that might be in order.
Dog parents have so many more options than ever before when it comes to treating and managing renal failure. Given advances in nutrition and drugs, the longevity of veterinary renal patients is most definitely on the rise. With your veterinarian's assistance, a long life for your pup is a possibility.
Source: Dr. Patty Khuly, VMD/MBA